Wigan recovered from their first defeat of the season by defeating Leigh and regained top spot.
The world champions scored eight tries as Lee suffered their fifth loss in their opening six matches.
Wigan had come out of their Good Friday defeat to St Helens wise and there was never any real doubt in this 'battle of the boroughs' against their neighbours.
Liam Marshall's seventh try of the season moved him joint top scorer with Leeds' Ash Hundley.
The loss to the Saints also cost the Warriors the performance of props Tyler Dupree and Liam Byrne, both of whom were suspended for offense in the game, but Lee may have had to make use of them. His low expectations were blown away by a series of tries.
Leigh got off to a bright start after kick-off was briefly delayed due to thick smoke from pre-match fireworks, but their first mistake saw Wigan press hard and Abbas Miski took the lead with a well-taken corner kick.
Leopards then lost the ball when Wigan's Jay Field made head contact with Matt Moylan as he slipped, but Wigan attacked again and Willie Isa collected a delicate kick from Bevan French to score.
French, who celebrates a new four-year contract this week, added another goal from his own kick, with Harry Smith scoring under the posts as Leigh struggled to cope with Wigan's power and pace.
Josh Charnley's soccer-style footwork gave Lee's first try to the returning Ricky Leutere, giving them hope of a second-half comeback.
It disappeared faster than fireworks smoke as Field scored his first try of the season from just outside his own 10-metre line and Adam Keeglan scored the next try off a looping pass from Smith.
The influential Smith was soon back in form, setting up 19-year-old Wiganer junior Nthemba to score his first Super League try before Leigh's Charnley grabbed a comfortable try against his old club.
Wigan rounded out the scoring as Marshall capitalized on a great break from Jake Wardle to score his seventh try of the season.
Lee: O'Brien. Hanley, Hardaker, Reutele, Charnley. Ram Moiran.Norman, McNamara, Trout, O'Donnell, Hulton, Hughes
Interchange: Nakbuwai, Davis, Dwyer, Chamberlain, Baxter.
Sin bin: Moylan (11)
Wigan: Field; Miski, Keiglan, Wardle, Marshall. Frenchman, Smith. Thompson, O'Neill, Hill, Isa, Farrell, Ellis.
Interchange: Mago, Leeming, Nthemba, Chan, Eckersley.
Referee: jack smith