It was a strange night in Birmingham, with the atmosphere a bit more subdued compared to previous weeks and the level of darts in the show different.
Littler's 6-5 semi-final victory over Humphries was sublime, giving the teenager his sixth straight victory over the man who beat him in the world championship final in January.
The 17-year-old trailed 2-0 before winning five legs in a row, but Humphries forced a decisive opportunity and had a throw, but Littler, who averaged 107.23 points, claimed it.
Two-time Premier League winner Van Gerwen defeated Nathan Aspinall 6-4 in the quarter-finals and beat Michael Smith by the same score in the semi-finals despite averaging just 93.28 points. .
There were some bright moments in the final, such as Van Gerwen's 125 checkout, but there were also many poor darts, with an average of 90.38 points and Littler's 88.12 points.
Legs 3-6 saw four consecutive breaks exchanged, but Van Gerwen made it through with three consecutive breaks.
It was a long-awaited return to form for the three-time world champions, whose lack of form had begun to jeopardize their chances of making the playoffs.
Elsewhere, Peter Wright suffered a ninth defeat in the quarter-finals, but the Scot remained firmly planted at the bottom of the table.
Rob Cross lost a decision to Littler in the quarterfinals, losing in the opening round for the fifth consecutive week. On the other hand, finalist Gerwyn Price, who lost last week, also finished sixth in the first round and is far from the play-off spots. Lost round to Smith.
