France host Wales in the first leg of the 2025 Six Nations on January 31, while England travel to Dublin on the opening weekend.
Ireland, the only team still chasing a Grand Slam in this year's championship, will host France in the fourth round.
After the trip to Dublin, England will play home games against France, Scotland and Italy.
Wales host England in Cardiff on the final weekend, Ireland away to Italy and France at home to Scotland.
It will be the first time the two sides have met in the final round since 2013, when Warren Gatland's side won the title with a 30-3 victory over England.
Scotland will be looking to make it five wins in a row against Steve Borthwick's side when they play on February 22nd.
The first two rounds will be played on consecutive weekends, with a two-week break before the third set of matches.
There will be an additional 14-day break before rounds four and five.
2025 Six Nations fixtures
Always Greenwich Mean Time
round 1
January 31st
France v Wales (20:15)
February 1
Scotland v Italy (14:15)
Ireland vs England (16:45)
round 2
February 8th
Italy v Wales (14:15)
England v France (16:45)
February 9th
Scotland v Ireland (15:00)
round 3
February 22
Wales v Ireland (14:15)
England v Scotland (16:45)
February 23rd
Italy v France (15:00)
round 4
March 8th
Ireland v France (14:15)
Scotland v Wales (16:45)
March 9
England v Italy (15:00)
round 5
March 16th
Italy v Ireland (14:15)
Wales v England (16:45)
France v Scotland (20:00)